Medical Q&As


I am taking methotrexate for arthritis. Can I take difene at the same time?

Methotrexate is a folic acid antagonist that is being increasingly used in the treatment of arthritis with encouraging results. It belongs to a category of treatments for arthritis known as “disease modifying agents” which means that they can alter the course of the disease rather then simply relieve the symptoms. Difene is a non-steroidal anti-inflammatory drug, which relieves pain and inflammation. Both methotrexate and difene can usually be taken together safely but do clarify this with your GP first.